mreb是一种肌动蛋白同系物，对于协调许多细菌杆状所需的细胞壁合成至关重要。Previously we have shown that filaments of MreB bind to the curved membranes of bacteria and translocate in directions determined by principal membrane curvatures to create and reinforce the rod shape (Hussain et al.,2018).Here,in order to understand how MreB filament dynamics affects their cellular distribution,we model how MreB filaments bind and translocate on membranes with different geometries.We find that it is both energetically favorable and robust for filaments to bind and orient along directions of largest membrane curvature.Furthermore,significant localization to different membrane regions results from processive MreB motion in various geometries.These results demonstrate that thein vivolocalization of MreB observed in many different experiments,including those examining negative Gaussian curvature,can arise from translocation dynamics alone.
- Felix Wong
- Ethan C Garner
资助者在研究设计中没有作用，data collection and interpretation,or the decision to submit the work for publication.
- Tâm Mignot,Aix Marseille University-CNRS UMR7283,France
- Received: August 2,2018
- Accepted: February 15,2019
- Accepted Manuscript published:February 18,2019 (version 1)
© 2019,Wong et al.
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