1. 微生物学与传染病
  2. Physics of Living Systems
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Mechanics and dynamics of translocating MreB filaments on curved membranes

  1. Felix Wong
  2. Ethan C Garner
  3. Ariel Amir Is a corresponding author
  1. Harvard University,United States
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Cite本文as:188bet体育电竞eLife 2019; 8: e40472 DOI:10.7554/188bet体育电竞eLife.40472

Abstract

mreb是一种肌动蛋白同系物,对于协调许多细菌杆状所需的细胞壁合成至关重要。Previously we have shown that filaments of MreB bind to the curved membranes of bacteria and translocate in directions determined by principal membrane curvatures to create and reinforce the rod shape (Hussain et al.,2018).Here,in order to understand how MreB filament dynamics affects their cellular distribution,we model how MreB filaments bind and translocate on membranes with different geometries.We find that it is both energetically favorable and robust for filaments to bind and orient along directions of largest membrane curvature.Furthermore,significant localization to different membrane regions results from processive MreB motion in various geometries.These results demonstrate that thein vivolocalization of MreB observed in many different experiments,including those examining negative Gaussian curvature,can arise from translocation dynamics alone.

文章和作者信息

Author details

  1. Felix Wong

    School of Engineering and Applied Sciences,Harvard University,Cambridge,United States
    Competing interests
    The authors declare that no competing interests exist.
    ORCID图标 "This ORCID iD identifies the author of this article:"0000-0002-2309-8835
  2. Ethan C Garner

    Department of Molecular and Cellular Biology,Harvard University,Cambridge,United States
    Competing interests
    The authors declare that no competing interests exist.
    ORCID图标 "This ORCID iD identifies the author of this article:"0000-0003-0141-3555
  3. Ariel Amir

    School of Engineering and Applied Sciences,Harvard University,Cambridge,United States
    For correspondence
    arielamir@seas.harvard.edu
    Competing interests
    The authors declare that no competing interests exist.
    ORCID图标 "This ORCID iD identifies the author of this article:"0000-0003-2611-0139

Funding

National Science Foundation (DGE1144152)

  • Felix Wong

National Institutes of Health (DP2AI117923-01)

  • Ethan C Garner

资助者在研究设计中没有作用,data collection and interpretation,or the decision to submit the work for publication.

Reviewing Editor

  1. Tâm Mignot,Aix Marseille University-CNRS UMR7283,France

出版历史

  1. Received: August 2,2018
  2. Accepted: February 15,2019
  3. Accepted Manuscript published:February 18,2019 (version 1)

Copyright

© 2019,Wong et al.

This article is distributed under the terms of theCreative Commons Attribution Licensepermitting unrestricted use and redistribution provided that the original author and source are credited.

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