The vast majority of the adult fly ventral nerve cord is composed of 34 hemilineages,which are clusters of lineally related neurons.Neurons in these hemilineages use one of the three fast-acting neurotransmitters (acetylcholine,GABA,or glutamate) for communication.We generated a comprehensive neurotransmitter usage map for the entire ventral nerve cord.We did not find any cases of neurons using more than one neurotransmitter,但发现乙酰胆碱特异性基因chat在许多谷氨酸和GABA能神经元中转录。但这些转录物通常不离开细胞核，也不被翻译。Importantly,our work uncovered a simple rule: All neurons within a hemilineage use the same neurotransmitter.Thus,neurotransmitter identity is acquired at the stem cell level.Our detailed transmitter- usage/lineage identity map will be a great resource for studying the developmental basis of behavior and deciphering how neuronal circuits function to regulate behavior.
- Tzumin Lee
- James W Truman
- Robert H Singer
资助者在研究设计中没有作用，data collection and interpretation,or the decision to submit the work for publication.
- K VijayRaghavan,National Centre for Biological Sciences,Tata Institute of Fundamental Research,India
- Accepted: March 23,2019
- Accepted Manuscript published:March 26,2019 (version 1)
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