1. Developmental Biology
  2. Neuroscience
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Neurotransmitter identity is acquired in a lineage-restricted manner in theDrosophila中枢神经系统

  1. Haluk Lacin Is a corresponding author
  2. Hui-Min Chen
  3. Xi Long
  4. Robert H Singer
  5. Tzumin Lee
  6. James W Truman
  1. Janelia Research Campus,Howard Hughes Medical Institute,United States
  2. Albert Einstein College of Medicine,United States
Research Article
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Cite本文as:188bet体育电竞eLife 2019;8:e43701 DOI:10.7554/188bet体育电竞eLife.43701

Abstract

The vast majority of the adult fly ventral nerve cord is composed of 34 hemilineages,which are clusters of lineally related neurons.Neurons in these hemilineages use one of the three fast-acting neurotransmitters (acetylcholine,GABA,or glutamate) for communication.We generated a comprehensive neurotransmitter usage map for the entire ventral nerve cord.We did not find any cases of neurons using more than one neurotransmitter,但发现乙酰胆碱特异性基因chat在许多谷氨酸和GABA能神经元中转录。但这些转录物通常不离开细胞核,也不被翻译。Importantly,our work uncovered a simple rule: All neurons within a hemilineage use the same neurotransmitter.Thus,neurotransmitter identity is acquired at the stem cell level.Our detailed transmitter- usage/lineage identity map will be a great resource for studying the developmental basis of behavior and deciphering how neuronal circuits function to regulate behavior.

文章和作者信息

作者详细信息

  1. Haluk Lacin

    Janelia Research Campus,Howard Hughes Medical Institute,AshburnUnited States
    For correspondence
    lacinhaluk@gmail.com
    Competing interests
    No competing interests declared.
    ORCID图标 "This ORCID iD identifies the author of this article:"0000-0003-2468-9618
  2. Hui-Min Chen

    Janelia Research Campus,Howard Hughes Medical Institute,AshburnUnited States
    Competing interests
    No competing interests declared.
  3. Xi Long

    Janelia Research Campus,Howard Hughes Medical Institute,AshburnUnited States
    Competing interests
    No competing interests declared.
  4. Robert H Singer

    Department of Anatomy and Structural Biology,Albert Einstein College of Medicine,New York,United States
    Competing interests
    Robert H Singer,Reviewing editor,188bet体育电竞.
    ORCID图标 "This ORCID iD identifies the author of this article:"0000-0002-6725-0093
  5. Tzumin Lee

    Janelia Research Campus,Howard Hughes Medical Institute,AshburnUnited States
    Competing interests
    No competing interests declared.
  6. James W Truman

    Janelia Research Campus,Howard Hughes Medical Institute,AshburnUnited States
    Competing interests
    No competing interests declared.
    ORCID图标 "This ORCID iD identifies the author of this article:"0000-0002-9209-5435

Funding

霍华德休斯医学院

  • Tzumin Lee
  • James W Truman

NIH Office of the Director (NS083086)

  • Robert H Singer

资助者在研究设计中没有作用,data collection and interpretation,or the decision to submit the work for publication.

Reviewing Editor

  1. K VijayRaghavan,National Centre for Biological Sciences,Tata Institute of Fundamental Research,India

出版历史

  1. 收到日期:11月16日,2018
  2. Accepted: March 23,2019
  3. Accepted Manuscript published:March 26,2019 (version 1)

Copyright

© 2019,拉辛等。

This article is distributed under the terms of theCreative Commons Attribution Licensepermitting unrestricted use and redistribution provided that the original author and source are credited.

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