Structural Biology and Molecular Biophysics

Structural Biology and Molecular Biophysics

188bet体育电竞eLife publishes research that uses techniques including X-ray crystallography,cryo-EM and single-molecule methods.Learn more about what we publishand sign up for the latest research.

Latest articles

    1. Structural Biology and Molecular Biophysics

    Structural and functional characterization of an otopetrin family proton channel

    Qingfeng Chen et al.
    Structural and functional analysis of the OTOP3 channel from Xenopus tropicalisoffers insights into the mechanism of ion transport and regulation in the otopetrin proton channel family.
    1. Structural Biology and Molecular Biophysics

    Binding and transport of D-aspartate by the glutamate transporter homolog GltTk

    Valentina Arkhipova et al.
    Glutamate transporter homologs can efficiently bind and transport both L- and D- enantiomeric substrates with only slight rearrangements in the binding site.
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    1. Structural Biology and Molecular Biophysics

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    Shivani Ahuja,Matthew R Whorton
    1. Structural Biology and Molecular Biophysics

    Enzyme activity and selectivity filter stability of ancient TRPM2 channels were simultaneously lost in early vertebrates

    Iordan Iordanov et al.
    Invertebrate TRPM2 channels have stable pores but act as chanzymes that hydrolyze their activating ligand ADP ribose (ADPR),whereas vertebrate TRPM2 channels are catalytically dead but undergo pore inactivation.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Functional instability allows access to DNA in longer transcription Activator-Like effector (TALE) arrays

    Kathryn Geiger-Schuller et al.
    Single molecule DNA-binding trajectories and deterministic modeling analyses demonstrate a functional role for high energy partly folded states in Transcription Activator-Like Effectors that could improve future TALEN design.
    1. Structural Biology and Molecular Biophysics

    Importin-9 wraps around the H2A-H2B core to act as nuclear importer and histone chaperone

    Abhilash Padavannil et al.
    In an unusual complex that is not dissociated by RanGTP alone,Importin-9 sequesters the H2A-H2B core from promiscuous interactions.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

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    Marijn de Boer et al.
    Selective import via bacterial ABC importers is facilitated by a hitherto unrecognized complexity in the conformational dynamics of the substrate-binding proteins.

Senior editors

  1. Richard Aldrich
    Richard Aldrich
    The University of Texas at Austin,United States
  2. Olga Boudker
    Weill Cornell Medicine,United States
  3. John Kuriyan
    John Kuriyan
    University of California,Berkeley,United States
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